解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:The discovery of cytosine hydroxymethylation (5hmC) as a mechanism that potentially controls DNA methylation changes typical of neoplasia prompted us to investigate its behaviour in colon cancer. 5hmC is globally reduced in proliferating cells such as colon tumours and the gut crypt progenitors, from which t...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-015-0605-5
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:While large-scale cancer genomic projects are comprehensively characterizing the mutational spectrum of various cancers, so far little attention has been devoted to either define the antigenicity of these mutations or to characterize the immune responses they elicit. Here we present a strategy to characteriz...
journal_title:Genome biology
pub_type: 杂志文章,meta分析
doi:10.1186/s13059-015-0620-6
更新日期:2015-03-31 00:00:00
abstract::A genomic analysis of heterogeneous colorectal tumor samples has uncovered interactions between immunophenotype and various aspects of tumor biology, with implications for informing the choice of immunotherapies for specific patients and guiding the design of personalized neoantigen-based vaccines. ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-015-0631-3
更新日期:2015-03-31 00:00:00
abstract::Field pathogenomics adds highly informative data to surveillance surveys by enabling rapid evaluation of pathogen variability, population structure and host genotype. ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-015-0615-3
更新日期:2015-03-02 00:00:00
abstract::The N 6-methyladenosine (m6A) modification of mRNA has a crucial function in regulating pluripotency in murine stem cells: it facilitates resolution of naïve pluripotency towards differentiation. ...
journal_title:Genome biology
pub_type: 杂志文章,评审
doi:10.1186/s13059-015-0609-1
更新日期:2015-02-22 00:00:00
abstract::A combined approach of whole genome shotgun sequencing and ultra-high density linkage mapping using skim sequencing of a segregating population is effective for assembling allopolyploid genomes. ...
journal_title:Genome biology
pub_type: 信件
doi:10.1186/s13059-015-0585-5
更新日期:2015-01-31 00:00:00
abstract:BACKGROUND:While the song of all songbirds is controlled by the same neural circuit, the hormone dependence of singing behavior varies greatly between species. For this reason, songbirds are ideal organisms to study ultimate and proximate mechanisms of hormone-dependent behavior and neuronal plasticity. RESULTS:We pre...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-014-0578-9
更新日期:2015-01-29 00:00:00
abstract:BACKGROUND:Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease, with 30% to 40% of patients failing to be cured with available primary therapy. microRNAs (miRNAs) are RNA molecules that attenuate expression of their mRNA targets. To characterize the DLBCL miRNome, we sequenced miRNAs from 92 DLBCL and 15 ben...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-014-0568-y
更新日期:2015-01-29 00:00:00
abstract::Giving access to sequence and annotation data for genome assemblies is important because, while facilitating research, it places both assembly and annotation quality under scrutiny, resulting in improvements to both. Therefore we announce Avianbase, a resource for bird genomics, which provides access to data released ...
journal_title:Genome biology
pub_type: 信件
doi:10.1186/s13059-015-0588-2
更新日期:2015-01-29 00:00:00
abstract::The definition of cell identity is a central problem in biology. While single-cell RNA-seq provides a wealth of information regarding cell states, better methods are needed to map their identity, especially during developmental transitions. Here, we use repositories of cell type-specific transcriptomes to quantify ide...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-015-0580-x
更新日期:2015-01-22 00:00:00
abstract::A report on the 64th annual American Society of Human Genetics meeting held in San Diego, USA, 18-22 October, 2014. ...
journal_title:Genome biology
pub_type:
doi:10.1186/s13059-014-0562-4
更新日期:2014-12-17 00:00:00
abstract:BACKGROUND:Differences in 5-hydroxymethylcytosine, 5hmC, distributions may complicate previous observations of abnormal cytosine methylation statuses that are used for the identification of new tumor suppressor gene candidates that are relevant to human hepatocarcinogenesis. The simultaneous detection of 5-methylcytosi...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-014-0533-9
更新日期:2014-12-03 00:00:00
abstract::Two recent publications have demonstrated how delivering CRISPR nucleases provides a promising solution to the growing problem of bacterial antibiotic resistance. ...
journal_title:Genome biology
pub_type: 评论,杂志文章
doi:10.1186/s13059-014-0516-x
更新日期:2014-11-08 00:00:00
abstract::An exciting recent study examining the methylation profile of human brain tissue implicates early-life epigenetic disruption in the neurodevelopmental origin of schizophrenia. ...
journal_title:Genome biology
pub_type: 评论,杂志文章
doi:10.1186/s13059-014-0495-y
更新日期:2014-10-29 00:00:00
abstract:BACKGROUND:Legume roots show a remarkable plasticity to adapt their architecture to biotic and abiotic constraints, including symbiotic interactions. However, global analysis of miRNA regulation in roots is limited, and a global view of the evolution of miRNA-mediated diversification in different ecotypes is lacking. ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-014-0457-4
更新日期:2014-09-24 00:00:00
abstract::Interpretation of the clinical significance of genomic alterations remains the most severe bottleneck preventing the realization of personalized medicine in cancer. We propose a knowledge commons to facilitate collaborative contributions and open discussion of clinical decision-making based on genomic events in cancer...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-014-0438-7
更新日期:2014-08-27 00:00:00
abstract:BACKGROUND:The recent reports of two circular RNAs (circRNAs) with strong potential to act as microRNA (miRNA) sponges suggest that circRNAs might play important roles in regulating gene expression. However, the global properties of circRNAs are not well understood. RESULTS:We developed a computational pipeline to ide...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-014-0409-z
更新日期:2014-07-29 00:00:00
abstract::An intriguing recent study examines the role of miR-1202, a glutamate receptor regulating microRNA, in regulating major depressive disorder. ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-014-0421-3
更新日期:2014-07-26 00:00:00
abstract:BACKGROUND:Mitogen-activated protein kinases (MAPKs) are key regulators of immune responses in animals and plants. In Arabidopsis, perception of microbe-associated molecular patterns (MAMPs) activates the MAPKs MPK3, MPK4 and MPK6. Increasing information depicts the molecular events activated by MAMPs in plants, but th...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-6-r87
更新日期:2014-06-30 00:00:00
abstract:BACKGROUND:RNA editing encompasses a post-transcriptional process in which the genomically templated sequence is enzymatically altered and introduces a modified base into the edited transcript. Mammalian C-to-U RNA editing represents a distinct subtype of base modification, whose prototype is intestinal apolipoprotein ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-6-r79
更新日期:2014-06-19 00:00:00
abstract::Mapping-by-sequencing has emerged as a powerful technique for genetic mapping in several plant and animal species. As this resequencing-based method requires a reference genome, its application to complex plant genomes with incomplete and fragmented sequence resources remains challenging. We perform exome sequencing o...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-6-r78
更新日期:2014-06-10 00:00:00
abstract::A report on the Cold Spring Harbor Asia conference on Genome Assisted Biology of Crops and Model Plant Systems Meeting, held in Suzhou, China, April 21-25, 2014. ...
journal_title:Genome biology
pub_type:
doi:10.1186/gb4176
更新日期:2014-05-23 00:00:00
abstract:BACKGROUND:Although genetic or epigenetic alterations have been shown to affect the three-dimensional organization of genomes, the utility of chromatin conformation in the classification of human disease has never been addressed. RESULTS:Here, we explore whether chromatin conformation can be used to classify human leu...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-4-r60
更新日期:2014-04-30 00:00:00
abstract:BACKGROUND:Retroviral elements are pervasively transcribed and dynamically regulated during development. While multiple histone- and DNA-modifying enzymes have broadly been associated with their global silencing, little is known about how the many diverse retroviral families are each selectively recognized. RESULTS:He...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-4-r58
更新日期:2014-04-30 00:00:00
abstract::Transcription factor binding sites compete for a limited pool of bioavailable transcription factor molecules to fine tune gene expression. ...
journal_title:Genome biology
pub_type: 评论,杂志文章
doi:10.1186/gb4174
更新日期:2014-04-28 00:00:00
abstract:BACKGROUND:There is tremendous potential for genome sequencing to improve clinical diagnosis and care once it becomes routinely accessible, but this will require formalizing research methods into clinical best practices in the areas of sequence data generation, analysis, interpretation and reporting. The CLARITY Challe...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-3-r53
更新日期:2014-03-25 00:00:00
abstract:BACKGROUND:Osteogenesis is a highly regulated developmental process and continues during the turnover and repair of mature bone. Runx2, the master regulator of osteoblastogenesis, directs a transcriptional program essential for bone formation through genetic and epigenetic mechanisms. While individual Runx2 gene target...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-3-r52
更新日期:2014-03-21 00:00:00
abstract:BACKGROUND:Cell lineage-specific DNA methylation patterns distinguish normal human leukocyte subsets and can be used to detect and quantify these subsets in peripheral blood. We have developed an approach that uses DNA methylation to simultaneously quantify multiple leukocyte subsets, enabling investigation of immune m...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-3-r50
更新日期:2014-03-05 00:00:00
abstract:BACKGROUND:Sensing and responding to ambient temperature is important for controlling growth and development of many organisms, in part by regulating mRNA levels. mRNA abundance can change with temperature, but it is unclear whether this results from changes in transcription or decay rates, and whether passive or activ...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-3-r45
更新日期:2014-03-03 00:00:00
abstract::Bisulfite sequencing (BS-seq) is the gold standard for studying genome-wide DNA methylation. We developed MOABS to increase the speed, accuracy, statistical power and biological relevance of BS-seq data analysis. MOABS detects differential methylation with 10-fold coverage at single-CpG resolution based on a Beta-Bino...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-2-r38
更新日期:2014-02-24 00:00:00
abstract:BACKGROUND:Pluripotency of embryonic stem (ES) cells is controlled in part by chromatin-modifying factors that regulate histone H3 lysine 4 (H3K4) methylation. However, it remains unclear how H3K4 demethylation contributes to ES cell function. RESULTS:Here, we show that KDM5B, which demethylates lysine 4 of histone H3...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-2-r32
更新日期:2014-02-04 00:00:00
abstract::Piwi-interacting RNAs (piRNAs) originate from genomic regions dubbed piRNA clusters. How cluster transcripts are selected for processing into piRNAs is not understood. We discuss evidence for the involvement of chromatin structure and maternally inherited piRNAs in determining their fate. ...
journal_title:Genome biology
pub_type: 杂志文章,评审
doi:10.1186/gb4154
更新日期:2014-01-27 00:00:00
abstract:BACKGROUND:ADAR proteins are among the most extensively studied RNA binding proteins. They bind to their target and deaminate specific adenosines to inosines. ADAR activity is essential, and the editing of a subset of their targets is critical for viability. Recently, a huge number of novel ADAR targets were detected b...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-1-r5
更新日期:2014-01-07 00:00:00
abstract:BACKGROUND:Long noncoding RNAs (lncRNAs) form an abundant class of transcripts, but the function of the majority of them remains elusive. While it has been shown that some lncRNAs are bound by ribosomes, it has also been convincingly demonstrated that these transcripts do not code for proteins. To obtain a comprehensiv...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-1-r6
更新日期:2014-01-07 00:00:00
abstract:BACKGROUND:RNA-binding proteins regulate a number of cellular processes, including synthesis, folding, translocation, assembly and clearance of RNAs. Recent studies have reported that an unexpectedly large number of proteins are able to interact with RNA, but the partners of many RNA-binding proteins are still uncharac...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2014-15-1-r13
更新日期:2014-01-02 00:00:00
abstract::MiRNAs play important roles in many diseases including cancers. However computational prediction of miRNA target genes is challenging and the accuracies of existing methods remain poor. We report mirMark, a new machine learning-based method of miRNA target prediction at the site and UTR levels. This method uses experi...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-014-0500-5
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Protein synthesis is tightly regulated and alterations to translation are characteristic of many cancers.Translation regulation is largely exerted at initiation through the eukaryotic translation initiation factor 4 F (eIF4F). eIF4F is pivotal for oncogenic signaling as it integrates mitogenic signals to amp...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/s13059-014-0476-1
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Drug resistance remains a major public health challenge for malaria treatment and eradication. Individual loci associated with drug resistance to many antimalarials have been identified, but their epistasis with other resistance mechanisms has not yet been elucidated. RESULTS:We previously described two mut...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/PREACCEPT-1067113631444973
更新日期:2014-01-01 00:00:00
abstract::A report on the Epigenetic Engineering Meeting hosted by the Barts Institute of Cancer, held in London, UK, May 7, 2014. ...
journal_title:Genome biology
pub_type:
doi:10.1186/gb4179
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The genomic binding of CTCF is highly conserved across mammals, but the mechanisms that underlie its stability are poorly understood. One transcription factor known to functionally interact with CTCF in the context of X-chromosome inactivation is the ubiquitously expressed YY1. Because combinatorial transcri...
journal_title:Genome biology
pub_type: 杂志文章
doi:10.1186/gb-2013-14-12-r148
更新日期:2013-12-31 00:00:00